Assessment on facile Diels–Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds

Natural Products and Bioprospecting

Duvvuru Gunasekar¹  Dmitry S. Kopchuk²  Grigory V. Zyryanov²  Aluru Rammohan²  Oleg N. Chupakhin²  Albert F. Khasanov² 

[1] Natural Products Division, Department of Chemistry, Sri Venkateswara University;Ural Federal University;

关键词: α-Pyrone;    Diels–Alder reaction (DAR);    Marine natural compounds;    Terpenoquinone;    Total synthesis;   

DOI  :  10.1007/s13659-022-00333-4

来源: DOAJ

【 摘 要 】

Abstract The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand. As this aspect, the Diels–Alder reaction (DAR) has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic scaffolds. Additionally, α-pyrone and terpenoquinone are two versatile key intermediates that are prevalent in various bioactive natural compounds for instance, (±)-crinine, (±)-joubertinamine, (±)-pancratistatin, (−)-cyclozonarone, and 8-ephipuupehedione, etc. Hence, the current review summarizes the Diels–Alder reaction application of α-pyrone and terpenoquinone to the constructive synthesis of various natural products over the past two decades (2001–2021). Equally, it serves as a stencil for the invention and development of new synthetic strategies for high-complex molecular structured natural and heterocyclic molecules. Graphical Abstract

【 授权许可】

Unknown