A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile

Viruses

Dusan Boric-Bargetto¹  GregoryJ. Mertz²  Cecilia Vial³  Fernando Torres-Pérez³  Constanza Martínez-Valdebenito⁴  R.Eduardo Palma⁵  PabloA. Vial⁶  Carlos Pavletic⁶  Alonso Parra⁷  PabloA. Marquet⁷  Marcela Ferrés⁸ 

[1] Santiago 8331150, Chile;Departamento de Ecología, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile;Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, Chile;Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago 7610658, Chile;Laboratorio de Biología Evolutiva, Departamento de Ecología, Pontificia Universidad Católica de Chile;Laboratorio de Infectología y Virología Molecular, Red Salud UC-Christus, Departamento de Enfermedades Infecciosas e Inmunología Pediátricas, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile;Oficina de Zoonosis y Control de Vectores, División de Políticas Publicas Saludables y Promoción, Subsecretaría de Salud Pública, Ministerio de Salud, Santiago 8320064, Chile;Programa Hantavirus, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago 7610658, Chile;

关键词: Andes orthohantavirus;    Chile;    hantavirus cardiopulmonary syndrome;    hantavirus spatial distribution;    Oligoryzomys longicaudatus;    peridomestic;    rodent reservoir;    seroprevalence;   

DOI  :  10.3390/v11090848

来源: DOAJ

【 摘 要 】

Small mammals present in areas where hantavirus cardiopulmonary syndrome (HCPS) cases had occurred in central and southern Chile were captured and analyzed to evaluate the abundance of rodents and seroprevalence rates of antibodies to Andes orthohantavirus (ANDV). Sampling areas ranged from the Coquimbo to Aysén regions (30−45° S approx.) regions. Ninety-two sites in peridomestic and countryside areas were evaluated in 19 years of sampling. An antibody against ANDV was detected by strip immunoassay in 58 of 1847 specimens captured using Sherman traps. Of the eleven species of rodents sampled, Abrothrix olivacea, Oligoryzomys longicaudatus and Abrothrix hirta were the most frequently trapped. O. longicaudatus had the highest seropositivity rate, and by logistic regression analysis, O. longicaudatus of at least 60 g had 80% or higher probability to be seropositive. Sex, age and wounds were significantly related to seropositivity only for O. longicaudatus. Across administrative regions, the highest seropositivity was found in the El Maule region (34.8−36.2° S), and the highest number of HCPS cases was registered in the Aysén region. Our results highlight the importance of long term and geographically extended studies, particularly for highly fluctuating pathogens and their reservoirs, to understand the implications of the dynamics and transmission of zoonotic diseases in human populations.

【 授权许可】

Unknown