MIBG Therapy for Neuroblastoma: Precision Achieved With Dosimetry, and Concern for False Responders

Frontiers in Medicine

Pedro M. Rubio¹  Leopoldo Martínez²  Sonia Rodado³  Diego Plaza⁴  Victor Galán⁴ 

[1] Investigación Traslacional en Cáncer Infantil, Trasplante Hematopoyético y Terapia Celular, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain;Network for Maternal and Children Health SAMID (RD16/0022/0006), Instituto de Salud Carlos III, Madrid, Spain;Nuclear Medicine Department, Hospital Universitario La Paz, Madrid, Spain;Pediatric Hemato-Oncology Department, Hospital Universitario La Paz, Madrid, Spain;Pediatric Surgery Department, Hospital Universitario La Paz, Madrid, Spain;

关键词: dosimetry;    mIBG;    neuroblastoma;    mIBG therapy;    false responder;   

DOI  :  10.3389/fmed.2020.00173

来源: DOAJ

【 摘 要 】

Neuroblastoma causes 15% of cancer mortality in children. High risk neuroblastoma has poor prognosis, with high relapse rate and mortality despite multimodal treatment. 123-I-meta-iodo-benzyl-guanidine (mIBG) scintigraphy is one of the current standard diagnostic procedures in neuroblastoma. mIBG can also be used therapeutically, labeled with 131-I, as a radiopharmaceutical agent, delivering targeted radiotherapy to tumoral sites. But published data of this strategy show heterogeneous results. One concern is that in most reports the infused activity is only based in body-weight, which could lead to infra or over-treatment, depending on inter-patient variability in radiation absorption. Activity adjustment by whole-body dosimetry can be used to homogeneize the treatment. Also, mIBG avid tumors may lose avidness along the treatment. As mIBG is used both for treatment and response evaluation, this could result in undetected progressions in patients with apparent complete response. We present a retrospective single-center review of neuroblastoma patients who received therapeutic 131-I-mIBG, focusing on cases with dosimetry-adjusted activity. Dosimetry allowed for a more precise delivery of radiation, reducing 81.1% of deviation from absorption target of 4 Gray (Gy), from 23.4% (±0.936 Gy) to 4.4% (± 0.176 Gy). Patients who showed partial or complete response had better and longer survival. Relapse/progression in non-responders was an early event (within 3 months from treatment). We also present one case of progression with apparent complete response due to loss of mIBG avidness, detected in our series.

【 授权许可】

Unknown