Withaferin-A down-regulate enterohepatic circulation of bile acids: An insight from a hyperlipidemic rat model

Journal of Agriculture and Food Research

Parvati Huded¹  Ramaprasad Ravichandra Talahalli¹  Mehrdad Zarei²  Sadashivaiah Bettadahalli²  Vinayak Uppin²  Nayana Venugopal²  Pooja Acharya² 

[1] Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India;Dept. of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, Karnataka, India;

关键词: Apical sodium-dependent bile acid transporter;    Cholesterol 7-α hydroxylase;    HMG-CoA;    Hyperlipidemia;    Withaferin-A;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hyperlipidemia is a metabolic abnormality in both young and aged populations across the world. Withaferin-A (WT) present in Withania somnifera (Indian ginseng) has been studied by many investigators for their therapeutic potentials. However, their effects on bile acid (BA) metabolism, that play a significant role in lipid homeostasis under hyperlipidemia has not been studied. This study explores the modulatory potential of WT on BA metabolism in young and aged hyperlipidemic rats. Hyperlipidemia was induced by feeding lard fat (35g/100g diet, HF) for 60 days. Withaferin-A (2.5 mg/kg diet) was fed to assess its effect on lipid metabolism and enterohepatic circulation of BA. In both models, compared to HF, WT had significantly (p < 0.05), decreased serum lipids, BA uptake, and HMG-CoA reductase activity, but increased hepatic Cyp7a1, decreased serum BA and increased fecal BA. WT re-regulated hyperlipidemia-induced aberrations in the intestinal uptake, hepatic synthesis, and cholesterol and BA metabolism in both models.

【 授权许可】

Unknown