Ribosome Fate during Decoding of UGA-Sec Codons

International Journal of Molecular Sciences

Paul R. Copeland¹  Michael T. Howard² 

[1] Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA;Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA;

关键词: selenocysteine;    selenoprotein;    SECIS;    recoding;    SECIS-binding protein;    translation termination;   

DOI  :  10.3390/ijms222413204

来源: DOAJ

【 摘 要 】

Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.

【 授权许可】

Unknown