Cerebellar rTMS for motor control in progressive supranuclear palsy

Brain Stimulation

W.H. DeVries¹  M. Mancini²  M.S. George³  M.L. Dale⁴ 

[1] Murray Center for Research on Parkinson's &Related Disorders, Department of Neurology, Medical University of South Carolina, Charleston, SC, USA;Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA;Corresponding author. 3181 S.W. Sam Jackson Park Rd. Mail Code: OP32, Portland, OR, 97239, USA;

关键词: Progressive supranuclear palsy;    Cerebellum;    Transcranial magnetic stimulation;    Posturography;    Balance;    Speech;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders.Objective/hypothesis: Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP). Methods: We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment. Results: After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable. Conclusion: Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.

【 授权许可】

Unknown