Long Non-Coding RNA BLACAT1 in Human Cancers

OncoTargets and Therapy

关键词: lncrna;    blacat1;    cancer;    review;   

DOI  :  

来源: DOAJ

【 摘 要 】

Tao Ye,1 Xiaoqi Yang,1 Haoran Liu,1,2 Peng Lv,1 Zhangqun Ye1 1Department of Urology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, People’s Republic of ChinaCorrespondence: Zhangqun Ye Department of UrologyTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of ChinaTel/Fax [phone]Email [e-mail]: Long non-coding RNAs (lncRNAs) are a cluster of RNAs with more than 200 nucleotides in length, which lack protein-coding capacity. They are important regulators of numerous cellular processes, including gene transcription, translation, and posttranslational modification, especially in tumor initiation and progression. Aberrant expression of lncRNA bladder cancer–associated transcript 1 (BLACAT1) has been reported in various human cancers and was usually associated with unfavorable prognosis. Previous studies have revealed that dysregulation of BLACAT1 could promote the proliferation and metastasis of cancer cells. In this review, we summarize the present understanding of the functions and underlying mechanisms of BLACAT1 in the occurrence and development of various human cancers and discuss the roles of this lncRNA in cancers, including its promising application as a prognostic biomarker or a novel therapeutic target for malignancies.Keywords: lncRNA, BLACAT1, cancer, review

【 授权许可】

Unknown