Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system

Photoacoustics

Pim J. van den Berg¹  Wiendelt Steenbergen¹  Khalid Daoudi²  Hein J. Bernelot Moens³ 

[1] Biomedical Photonic Imaging, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede, The Netherlands;Medical Ultrasound Imaging Center, department of Radiology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands;Ziekenhuisgroep Twente, Department of Rheumatology, Postbus 546, 7550 AM Hengelo, The Netherlands;

关键词: Rheumatoid arthritis;    Synovitis;    Photoacoustic;    Optoacoustic;    Medical ultrasound;    Echography;    Ultrasonography;    Proof of principle;    Feasibility study;   

DOI  :  10.1016/j.pacs.2017.08.002

来源: DOAJ

【 摘 要 】

We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman’s ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.

【 授权许可】

Unknown