Omics techniques and biobanks to find new biomarkers for the early detection of acute lymphoblastic leukemia in middle-income countries: a perspective from Mexico

Boletín Médico del Hospital Infantil de México

Hortensia Reyes-Morales¹  Albert Zlotnik²  Ricardo Valle-Rios³  William Alejandro Aguirre-Guillén³  Tania Angeles-Floriano³  Briceida López-Martínez⁴ 

[1] Departamento de Investigación, Hospital Infantil de México Federico Gómez, Mexico City, Mexico;Department of Physiology and Biophysics and Institute for Immunology, University of California Irvine, Irvine, CA, USA;Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Mexico City, Mexico;Sub-Dirección de Diagnóstico Clínico, Hospital Infantil de México Federico Gómez, Mexico City, Mexico;

关键词: Acute lymphoblastic leukemia;    Omics techniques;    Biobanks;   

DOI  :  10.1016/j.bmhimx.2017.03.007

来源: DOAJ

【 摘 要 】

Acute lymphoblastic leukemia (ALL) affects the quality of life of many children in the world and particularly in Mexico, where a high incidence has been reported. With a proper financial investment and with well-organized institutions caring for those patients, together with solid platforms to perform high-throughput analyses, we propose the creation of a Mexican repository system of serum and cells from bone marrow and blood samples derived from tissues of pediatric patients with ALL diagnosis. This resource, in combination with omics technologies, particularly proteomics and metabolomics, would allow longitudinal studies, offering an opportunity to design and apply personalized ALL treatments. Importantly, it would accelerate the development of translational science and will lead us to further discoveries, including the identification of new biomarkers for the early detection of leukemia.

【 授权许可】

Unknown