Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation

Frontiers in Neuroscience

Eberhard E. Fetz¹  Larry E. Shupe¹  Jonathan Mishler²  Irene Rembado²  R. Logan Murphy³  Steve I. Perlmutter³  Richy Yun⁴  Frank P. Miles⁵  Geoff Jones⁵ 

[1] Biophysics, University of Washington, Seattle, WA, United States;Department of Bioengineering, University of Washington, Seattle, WA, United States;;Department of Physiology &Independent Researcher, Seattle, CA, United States;Washington National Primate Research Center, University of Washington, Seattle, WA, United States;

关键词: brain-computer interface;    neuroprosthetics;    closed-loop stimulation;    neural recording;    neural stimulation;    neurochip;   

DOI  :  10.3389/fnins.2021.718465

来源: DOAJ

【 摘 要 】

Toward addressing many neuroprosthetic applications, the Neurochip3 (NC3) is a multichannel bidirectional brain-computer interface that operates autonomously and can support closed-loop activity-dependent stimulation. It consists of four circuit boards populated with off-the-shelf components and is sufficiently compact to be carried on the head of a non-human primate (NHP). NC3 has six main components: (1) an analog front-end with an Intan biophysical signal amplifier (16 differential or 32 single-ended channels) and a 3-axis accelerometer, (2) a digital control system comprised of a Cyclone V FPGA and Atmel SAM4 MCU, (3) a micro SD Card for 128 GB or more storage, (4) a 6-channel differential stimulator with ±60 V compliance, (5) a rechargeable battery pack supporting autonomous operation for up to 24 h and, (6) infrared transceiver and serial ports for communication. The NC3 and earlier versions have been successfully deployed in many closed-loop operations to induce synaptic plasticity and bridge lost biological connections, as well as deliver activity-dependent intracranial reinforcement. These paradigms to strengthen or replace impaired connections have many applications in neuroprosthetics and neurorehabilitation.

【 授权许可】

Unknown