A Genome-wide Scan for Selective Sweeps in Racing Horses

Asian-Australasian Journal of Animal Sciences

Donghyun Shin¹  Sunjin Moon¹  Heebal Kim¹  Ik-Young Choi²  Jin Woo Lee³  Jun Kim⁴  Kwang-Yun Shin⁴  Jaemin Kim⁵ 

[1] Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea;Genome analysis center, National Instrumentation and Environmental Management (NICEM), Seoul National University, Seoul 151-921, Korea;Horse Registry, Korea Racing Authority (KRA), Gwacheon 427-711, Korea;Institute for Livestock Promotion, Jeju 690-802, Korea;Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Korea;

关键词: Single Nucleotide Polymorphism;    Racehorse;    Selective Sweep;    Quantitative Trait Loci;   

DOI  :  10.5713/ajas.14.0696

来源: DOAJ

【 摘 要 】

Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.

【 授权许可】

Unknown