Beyond thrombosis: the impact of tissue factor signaling in cancer

Journal of Hematology & Oncology

Dusten Unruh¹  Craig Horbinski¹ 

[1] Department of Neurological Surgery, Northwestern University;

关键词: Tissue factor;    Protease-activated receptors;    Receptor tyrosine kinases;    Integrins;    Metastasis;    Angiogenesis;   

DOI  :  10.1186/s13045-020-00932-z

来源: DOAJ

【 摘 要 】

Abstract Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also activate receptor tyrosine kinases (RTKs) and integrins. These signaling pathways are utilized by tumors to increase cell proliferation, angiogenesis, metastasis, and cancer stem-like cell maintenance. Herein, we review in detail the regulation of TF expression, mechanisms of TF signaling, their pathological consequences, and how it is being targeted in experimental cancer therapeutics.

【 授权许可】

Unknown