Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer

Journal of Translational Medicine

Anne Tuomisto¹  Juha P. Väyrynen¹  Tuomo J. Karttunen¹  Markus J. Mäkinen¹  Päivi Sirniö¹  Ilkka Minkkinen¹  Sara A. Väyrynen¹  Toni Karhu²  Karl-Heinz Herzig²  Kai Klintrup³  Jyrki Mäkelä³ 

[1] Cancer and Translational Medicine Research Unit, University of Oulu;Research Unit of Biomedicine and Biocenter of Oulu, University of Oulu;Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu;

关键词: Thrombocytosis;    Colorectal cancer;    Inflammation;    Prognosis;    Aspirin;    Platelet;   

DOI  :  10.1186/s12967-019-1950-z

来源: DOAJ

【 摘 要 】

Abstract Background Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of tumor infiltrating immune cells, and survival in colorectal cancer (CRC), and these relationships could be altered by aspirin use. Methods We measured blood platelet count in a cohort of 356 CRC patients and analyzed its relationships with tumor and patient characteristics including aspirin use, markers of systemic inflammation (modified Glasgow Prognostic Score, mGPS; serum levels of CRP, albumin, and 13 cytokines), blood hemoglobin levels, five types of tumor infiltrating immune cells (CD3, CD8, FoxP3, Neutrophil elastase, mast cell tryptase), and survival. Results Platelet count inversely correlated with blood hemoglobin levels (p < 0.001) and positively correlated with serum levels of CRP and multiple cytokines including IL-1RA, IL-4, IL-6, IL-7, IL-8, IL-12, IFNγ, and PDGF-BB (p < 0.001 for all), while aspirin use was not associated with the levels of systemic inflammatory markers. High platelet count was also associated with high mGPS (p < 0.001) but did not show statistically significant multivariable adjusted associations with the densities of tumor infiltrating immune cells. Higher platelet counts were observed in higher tumor stage (p < 0.001), but platelet count or aspirin use were not associated with patient survival. Conclusions High platelet count is associated with systemic inflammation in CRC. This study could not demonstrate statistically significant associations between platelet count, aspirin use, and the densities of tumor infiltrating immune cells.

【 授权许可】

Unknown