A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

Emerging Microbes and Infections

Wei Zhang¹  Guo Fu¹  Chenfeng Liu²  Yanling Wen³  Quan Yuan³  Mujin Fang⁴  Weibin Zheng⁵  Guofeng Fu⁵  Jun Zhang⁵  Ningshao Xia⁶  Zheng Zhang⁶  Boya Zhang⁶  Xiaofen Huang⁶  Bo-Sheng Pan⁶  Yixin Chen⁶  Yahua Lin⁶  Junyu Chen⁶  Xin Wang⁶  Zizheng Zheng⁶  Shaowei Li⁶  Xiaochen Yin⁶  Qinjian Zhao⁶  Chenguang Shen⁶  Yufang Li⁶ 

[1] The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of China;Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei, People’s Republic of China;Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital;Reverie Labs, Cambridge, MA, USA;School of Life Science, Xiamen University, Xiamen, People’s Republic of China;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, People’s Republic of China;

关键词: Prophylactic;    influenza;    respiratory syncytial virus;    alveolar macrophage;    interferon;   

DOI  :  10.1080/22221751.2022.2050951

来源: DOAJ

【 摘 要 】

Infection caused by respiratory viruses can lead to a severe respiratory disease and even death. Vaccination is the most effective way to prevent the disease, but it cannot be quickly applied when facing an emerging infectious disease. Here, we demonstrated that immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone, bearing great resemblance in morphology with commonly used aluminium-based adjuvants in vaccines, could quickly induce mice to generate a broadly protective immune response to resist the lethal challenge of influenza B viruses. Furthermore, a multi-omics-based analysis revealed that the alveolar macrophage and type I interferon pathway, rather than adaptive immunity and type II interferon pathway, were essential for the observed prophylactic effect of FH-001. More importantly, a similar protective effect was observed against influenza A virus strain A/Shanghai/02/2013(H7N9), A/California/04/2009(H1N1) and respiratory syncytial virus. Therefore, we introduced here a new and promising strategy that can be quickly applied during the outbreak of emerging respiratory viruses.

【 授权许可】

Unknown