Neopterin is a biomarker of chronic heart failure (review of modern literature)

Consilium Medicum

Ramiz K. Valiev¹  Madina F. Akhmedova²  Igor G. Nikitin³  Marina R. Kalova³  Elvina T. Gasanova³  Kira V. Voronkova³  Tatiana V. Pinchuk³  Amina M. Alieva³  Olga A. Ettinger³  Lidiia M. Shnakhova⁴ 

[1] Loginov Moscow Clinical Scientific and Practical Center;Multipurpose Medical Center “AKFA Medline”;Pirogov Russian National Research Medical University;Sechenov First Moscow State Medical University (Sechenov University);

关键词: chronic heart failure;    neopterin;    biomarker;    left ventricle;    ejection fraction;   

DOI  :  10.26442/20751753.2021.10.201113

来源: DOAJ

【 摘 要 】

Inflammation plays a role in the pathogenesis of heart failure. Neopterin, pteridine, synthesized mainly by activated macrophages, is a marker of inflammation, activation of the immune system, and an active participant in cardiovascular disease. Measuring neopterin levels can help track the evolution of specific inflammatory conditions. In addition, neopterin was associated with cardiac dysfunction after cardiac surgery and improved the accuracy of predicting the risk of postoperative cardiac dysfunction. In this review, we provide current insights into neopterin and its relationship to heart failure.

【 授权许可】

Unknown