High-Normal Serum Magnesium and Hypermagnesemia Are Associated With Increased 30-Day In-Hospital Mortality: A Retrospective Cohort Study

Frontiers in Cardiovascular Medicine

Liao Tan²  Jie Liu²  Ruizheng Shi²  Chan Li²  Qian Xu³ 

[1] Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China;Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China;Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, China;

关键词: serum magnesium;    ICU;    acute myocardial infarction;    in-hospital mortality;    prediction;   

DOI  :  10.3389/fcvm.2021.625133

来源: DOAJ

【 摘 要 】

Background: Magnesium, the fourth most abundant mineral nutrient in our body, plays a critical role in regulating ion channels and energy generation, intracardiac conduction, and myocardial contraction. In this study, we assessed the association of admission serum magnesium level with all-cause in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).Methods: Clinical data were extracted from the eICU Collaborative Research Database (eICU-CRD). Only the data for the first intensive care unit (ICU) admission of each patient were used, and baseline data were extracted within 24 h after ICU admission. Logistic regression, Cox regression, and subgroup analyses were conducted to determine the relationship between admission serum magnesium level and 30-day in-hospital mortality in ICU patients with AMI.Results: A total of 9,005 eligible patients were included. In the logistic regression analysis, serum magnesium at 2.2 to ≤2.4 and >2.4 mg/dl levels were both significant predictors of all-cause in-hospital mortality in AMI patients. Moreover, serum magnesium of 2.2 to ≤2.4 mg/dl showed higher risk of in-hospital mortality than magnesium of >2.4 mg/dl (adjusted odds ratio, 1.63 vs. 1.39). The Cox regression analysis yielded similar results (adjusted hazard ratio, 1.36 vs. 1.25).Conclusions: High-normal serum magnesium and hypermagnesemia may be useful and easier predictors for 30-day in-hospital mortality in critically ill patients with AMI.

【 授权许可】

Unknown