(Dis)similarities between the Decidual and Tumor Microenvironment

Biomedicines

Daniela Gold¹  Ursula Hiden¹  Tina Gorsek Sparovec¹  Gerit Moser²  Julia Feichtinger²  Martin Gauster²  Julian Christopher Krappinger²  Berthold Huppertz²  Julia Fuchs²  Jelena Krstic²  Marta Szmyra³  Katrin Pansy³  Alexander Deutsch³ 

[1] Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria;Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria;Division of Hematology, Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria;

关键词: decidual microenvironment;    tumor microenvironment;    placenta;    immune cells;    proliferation;    invasion;   

DOI  :  10.3390/biomedicines10051065

来源: DOAJ

【 摘 要 】

Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and escape the immune system. Importantly, both trophoblast and tumor cells are supported by an abetting microenvironment, which influences invasion, angiogenesis, and immune tolerance/evasion, among others. However, in contrast to tumor cells, the metabolic, proliferative, migrative, and invasive states of trophoblast cells are under tight regulatory control. In this review, we provide an overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate, particularly focusing on the role of the abetting microenvironments.

【 授权许可】

Unknown