The Heating Efficiency and Imaging Performance of Magnesium Iron Oxide@tetramethyl Ammonium Hydroxide Nanoparticles for Biomedical Applications

Nanomaterials

Minh Phu Bui¹  Mohamed S. A. Darwish¹  Tuan-Anh Le¹  Hohyeon Kim¹  Jungwon Yoon¹  Chiseon Ryu²  Hwangjae Lee²  Jae Young Lee² 

[1] School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju 61005, Korea;School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea;

关键词: hyperthermia;    magnesium iron oxide;    magnetic particle imaging;    nanoparticle;   

DOI  :  10.3390/nano11051096

来源: DOAJ

【 摘 要 】

Multifunctional magnetic nanomaterials displaying high specific loss power (SLP) and high imaging sensitivity with good spatial resolution are highly desired in image-guided cancer therapy. Currently, commercial nanoparticles do not sufficiently provide such multifunctionality. For example, Resovist^® has good image resolution but with a low SLP, whereas BNF^® has a high SLP value with very low image resolution. In this study, hydrophilic magnesium iron oxide@tetramethyl ammonium hydroxide nanoparticles were prepared in two steps. First, hydrophobic magnesium iron oxide nanoparticles were fabricated using a thermal decomposition technique, followed by coating with tetramethyl ammonium hydroxide. The synthesized nanoparticles were characterized using XRD, DLS, TEM, zeta potential, UV-Vis spectroscopy, and VSM. The hyperthermia and imaging properties of the prepared nanoparticles were investigated and compared to the commercial nanoparticles. One-dimensional magnetic particle imaging indicated the good imaging resolution of our nanoparticles. Under the application of a magnetic field of frequency 614.4 kHz and strength 9.5 kA/m, nanoparticles generated heat with an SLP of 216.18 W/g, which is much higher than that of BNF (14 W/g). Thus, the prepared nanoparticles show promise as a novel dual-functional magnetic nanomaterial, enabling both high performance for hyperthermia and imaging functionality for diagnostic and therapeutic processes.

【 授权许可】

Unknown