Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate

Фармакоэкономика

A. M. Lila¹  T. B. Minasov²  I. Yu. Torshin³  O. A. Gromova⁴  N. V. Zagorodniy⁵ 

[1] Peoples' Friendship University of Russia;Bashkir State Medical University;Federal Research Center “Informatics and Management”, Russian Academy of Sciences;Nasonova Research Institute of Rheumatology;Priorov National Medical Research Center of Traumatology and Orthopedics;

关键词: joint endoprosthetics;    preoperative period;    postoperative rehabilitation;    osteoarthritis;    chondroprotection;    chondroitin sulfate;    glucosamine sulfate;   

DOI  :  10.17749/2070-4909/farmakoekonomika.2022.136

来源: DOAJ

【 摘 要 】

Joint endoprosthetics is a treatment of choice for patients with decompensated osteoarthritis (OA), who have exhausted the possibilities of pharmacotherapy and other methods of conservative treatment. Preparation for endoprosthetics and rehabilitation after surgery usually includes measures to improve the muscle condition and local blood circulation in the joint area, and if necessary, pain management. The unique spectrum of anti-inflammatory effect of chondroprotectors based on chondroitin sulfate and glucosamine sulfate includes inhibition of NF-κB cascade, toll-like receptors, pro-inflammatory cytokines, metalloproteinases, and significantly alleviates the course of OA. Reducing the severity of OA is important for preparing for surgery, subsequent rehabilitation, and preventing the revision surgery.

【 授权许可】

Unknown