A primary mediastinal germ cell tumor of yolk sac type: case report

The Pan African Medical Journal

Anass Khacha¹  Mustapha Maaroufi¹  Zineb Benbrahim²  Khadija Darif²  Karima Oualla²  Nisrine Acharfi²  Samia Arifi²  Nawfel Mellas²  Lamiae Amaadour² 

[1] Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco;Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco;

关键词: germ cell tumors;    yolk sac tumor;    mediastinum;    case report;   

DOI  :  10.11604/pamj.2021.38.330.23730

来源: DOAJ

【 摘 要 】

The mediastinal malignant germ cells tumor represent less than 0.5% of thoracic tumors, although the mediastinum is one of the main extragonadic locations of these tumors. In the majority of cases, young people are those most affected. The prognosis of mediastinal malignant germ cells tumors is poor, especially non-seminomatous germ tumors. In this article, we report a rare case of a young 19-years-old patient treated for a mediastinal germ cell tumor of yolk sac. The patient presented a chest pain; the chest CT showed a right paramedian mediastinal mass with a pleural effusion associated with supraclavicular and cervical lymph nodes. Biopsy revealed a non-seminomatousgerm cell tumor of yolk sac. The exams showed elevated alpha-fetoprotein (AFP), without any meaningful elevation of other serictumor markers. The patient received 4 cycles of chemotherapy based on etoposide, ifosfamide and platinum salts then a complete excision of the mass.

【 授权许可】

Unknown