Why clinical translation cannot succeed without failure

eLife

Alex John London¹  Jonathan Kimmelman² 

[1] Department of Philosophy and Center for Ethics and Policy, Carnegie Mellon University, Pittsburgh, United States;Studies of Translation, Ethics and Medicine Research Group, Biomedical Ethics Unit, McGill University, Montréal, Canada;

关键词: preclinical research;    clinical trials;    drug development;    ethics;    reproducibility;    translational research;   

DOI  :  10.7554/eLife.12844

来源: DOAJ

【 摘 要 】

The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and demonstrating the limits of proven drugs. A wider recognition of these benefits will help the biomedical research enterprise to take full advantage of all the information generated during the drug development process.

【 授权许可】

Unknown