Are Type 2 Diabetes Mellitus and Depression Part of a Common Clock Genes Network?

Journal of Circadian Rhythms

Gregory M. Brown¹  David Warren Spence²  Ramanujam Karthikeyan³  Seithikurippu R. Pandi-Perumal⁴ 

[1] Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, M5T 1R8;Dufferin Street, Toronto, ON M6K 2B4;Plot No.144, South 9th Street, Meenakshi Amman Nagar, Surya Nagar, Madurai 625007, Tamil Nadu;Somnogen Canada Inc, College Street, Toronto, ON;

关键词: Circadian rhythm;    Clock genes;    T2DM;    depression;    diabetes;   

DOI  :  10.5334/jcr.159

来源: DOAJ

【 摘 要 】

In recent years, there has been an increased prevalence of type 2 diabetes mellitus (T2DM) and depression across the world. This growing public health problem has produced an increasing socioeconomic burden to the populations of all affected countries. Despite an awareness by public health officials and medical researchers of the costs associated with these diseases, there still remain many aspects of how they develop that are not understood. In this article, we propose that the circadian clock could be a factor that coordinates both the neurobehavioral and metabolic processes that underlie depression and T2DM. We propose further that this perspective, one which emphasizes the regulatory effects of clock gene activity, may provide insights into how T2DM and depression interact with one another, and may thus open a new pathway for managing and treating these disorders.

【 授权许可】

Unknown