Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications

Journal of Hematology & Oncology

Yuhang Xiao¹  Hui Wang²  Min Su³  Deliang Cao³  Wenxiang Wang³  Junliang Ma³  Yong Zhou³  Qianjin Liao⁴ 

[1] Department of Pharmacy, Xiangya Hospital of Xiangya School of Medicine, Central South University;Department of Thoracic Radiotherapy, Key laboratory of Translational Radiation Oncology, Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University;Department of the 2nd Department of Thoracic Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University;Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University;

关键词: Long non-coding RNA;    Esophageal cancer;    Mechanism;    Application;    Biomarker;   

DOI  :  10.1186/s13045-018-0663-8

来源: DOAJ

【 摘 要 】

Abstract Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in the poor prognosis of EC. In addition, the underlying molecular mechanisms of EC development have yet to be elucidated. Accumulating evidence has demonstrated that lncRNAs play a vital role in the pathological progression of EC. LncRNAs may regulate gene expression through the recruitment of histone-modifying complexes to the chromatin and through interactions with RNAs or proteins. Recent evidence has demonstrated that the dysregulation of lncRNAs plays important roles in the proliferation, metastasis, invasion, angiogenesis, apoptosis, chemoradiotherapy resistance, and stemness of EC, which suggests potential clinical implications. In this review, we highlight the emerging roles and regulatory mechanisms of lncRNAs in the context of EC and discuss their potential clinical applications as diagnostic and prognostic biomarkers.

【 授权许可】

Unknown