Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice

Biomedicines

SusanV. Brooks¹  CarolS. Davis¹  JeAnnaR. Redd²  Ayat AL-Tamimi²  Dave Bridges²  LauraC. Gunder²  Innocence Harvey² 

[1] Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA;

关键词: glucocorticoids;    atrophy;    obesity;    atrogenes;    insulin resistance;   

DOI  :  10.3390/biomedicines8100420

来源: DOAJ

【 摘 要 】

Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that all animals treated with the synthetic glucocorticoid dexamethasone had reduced strength, but that obesity exacerbated this effect. These changes were concordant with more pronounced reductions in muscle size, particularly in Type II muscle fibers, and potentiated induction of atrogene expression in the obese mice relative to lean mice. Furthermore, we show that the reductions in lean mass do not fully account for the dexamethasone-induced insulin resistance observed in these mice. Together, these data suggest that obesity potentiates glucocorticoid-induced muscle atrophy.

【 授权许可】

Unknown