Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

European Pharmaceutical Journal

Upasani Chandrashekar D.¹  Mahajan Manojkumar S.¹  Upaganlawar Aman B.¹ 

[1] Shri Neminath Jain Brahmacharyashram Trust's, Shreeman Sureshdada Jain College of Pharmacy, Nashik, Maharashtra, India;

关键词: diabetic nephropathy;    oxidative stress;    streptozotocin;    coenzyme q10;    n-acetylcysteine;   

DOI  :  10.2478/afpuc-2020-0020

来源: DOAJ

【 摘 要 】

Oxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue damage to improve renal physiology during DN. The investigation, therefore, was designed to assess the nephroprotective effect of coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), either alone or in combination in streptozotocin (STZ)-nicotinamide (NAD) induced diabetic nephropathy (DN) in rats.

【 授权许可】

Unknown