Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

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James Mucunu Mbaria¹  Francis Okumu Ochola²  Paul Gichohi Mbuthia³  Kenneth Narotso Maloba⁴  Joseph Kangangi Gikunju⁵  Mitchel Otieno Okumu⁵  Joseph Gichuki Nderitu⁵  Vincent Odongo Madadi⁶ 

[1] Corresponding author. .;Department of Chemistry, University of Nairobi, Kenya;Department of Medical Laboratory Science, Jomo Kenyatta University of Agriculture and Technology, Kenya;Department of Pharmacology and Toxicology, Moi University, Kenya;Department of Public Health, Pharmacology, and Toxicology, University of Nairobi, Kenya;Department of Veterinary Pathology, Microbiology, and Parasitology, University of Nairobi, Kenya;

关键词: Snakebite;    Naja ashei;    Antivenoms;    Neutralization;    Potency;   

DOI  :  

来源: DOAJ

【 摘 要 】

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).

【 授权许可】

Unknown