Facile immobilization of heparin on bioabsorbable iron via mussel adhesive protein (MAPs)

Progress in Natural Science: Materials International

Xuchen Xu¹  Yuying Shi¹  Yan Cheng¹  Ming Li¹  Qian Liu¹  Yufeng Zheng¹  Zhaojun Jia¹  L.Q. Ruan² 

[1] Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;Department of Mechanical Systems Engineering, Graduate School of Science and Technology, Kumamoto University, Kurokami 2-39-1, Kumamoto-shi 860-8555, Japan;

关键词: Iron;    Heparin;    Dopamine;    Surface modification;    Biodegradable stent;    Hemocompatibility;   

DOI  :  10.1016/j.pnsc.2014.09.001

来源: DOAJ

【 摘 要 】

Motivated by adhesive proteins in mussels, strategies using dopamine to modified surface have become particularly attractive. In the present work, we developed a novel and convenient method to modify the biodegradable Fe plates with heparin. Iron was first treated by a facile one-step pH-induced polymerization of dopamine, and then a high density heparin was successfully grafted onto the surface via coupling with polydopamine (PDA) active layer. Heparin immobilization contributed much longer blood clotting coagulation time than the pure Fe sample, and hence reduced the risk of thrombosis. Cell viability tests suggested that the heparin modified Fe plates were more favorable to the proliferation of ECV304 cells. In summary, the heparin modified Fe plates with good anti-thrombus properties and inhibiting the proliferation of VSMC cells provide great prospects for biodegradable iron.

【 授权许可】

Unknown