Molecular Characterization and Clinical Relevance of ALDH2 in Human Cancers

Frontiers in Medicine

Libo Wang¹  Long Liu¹  Lingfang Meng²  Bo Ma³  Yuyuan Zhang³  Lifeng Li⁴  Xinwei Han⁶  Zaoqu Liu⁶  Hui Xu⁶  Tao Huang⁷ 

[1] Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Infection Management, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China;Interventional Institute of Zhengzhou University, Zhengzhou, China;Interventional Treatment and Clinical Research Center of Henan Provice, Zhengzhou, China;Medical School, Huanghe Science and Technology University, Zhengzhou, China;

关键词: ALDH2;    pan-cancer;    genetic alterations;    drug sensitivity;    immunotherapy;    survival;   

DOI  :  10.3389/fmed.2021.832605

来源: DOAJ

【 摘 要 】

Background: Aldehyde dehydrogenase 2 (ALDH2) is well-known to be a key enzyme in alcohol metabolism. However, a comprehensive understanding of ALDH2 across human cancers is lacking.Methods: A systematic and comprehensive analysis of the molecular alterations and clinical relevance for ALDH2 in more than 10,000 samples from 33 cancer types was performed. qRT-PCR was performed on 60 cancer and 60 paired nontumor tissues.Results: It was observed that ALDH2 was generally downregulated in most cancers, which was mainly driven by DNA hypermethylation rather than mutations or copy number variations. Besides, ALDH2 was closely related to the inhibition and activation of tumor pathways and a variety of potential targeted agents had been discovered in our research. Last but not least, ALDH2 had the best prediction efficacy in assessing immunotherapeutic response compared with PD-L1, PD-1, CTLA4, CD8, and tumor mutation burden (TMB) in cutaneous melanoma. According to the analysis of large-scale public data and 60 pairs of clinical cancer samples, we found the downregulation of ALDH2 expression tends to suggest the malignant phenotypes and adverse prognosis, which might enhance the precise diagnosis and timely intervention of cancer patients.Conclusion: This study advanced the understanding of ALDH2 across cancers, and provided important insight into chemotherapy, immunotherapy and prognosis of patients with cancer.

【 授权许可】

Unknown