Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae) for antiulcer property

Saudi Journal of Biological Sciences

Fahad M.A. Al-Hemaid¹  Mohammad Ajmal Ali¹  Senguttuvan Jamuna²  Subramaniam Paulsamy²  Chinnamaruthu Jayachitra³ 

[1] Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;Department of Botany, Kongunadu Arts and Science College, Coimbatore 641029, India;Research and Development Cell, Bharathiar University, Coimbatore 641046, India;

关键词: Aerial parts;    Acute toxicity;    Pylorus ligation;    Ethanol induced ulcer;   

DOI  :  10.1016/j.sjbs.2017.03.007

来源: DOAJ

【 摘 要 】

Cissus setosa is an indigenous medicinal herb commonly used for the treatment of gastro ulcers. In the current investigation the aerial methanolic extract of C. setosa was investigated for their antiulcer activity using pylorus ligation and ethanol in experimental rats. The extract was administered at the doses of 200 and 400 mg/kg b.w. orally for 3 days. However, higher dose of the extract subsequently reduced gastric ulcer induced aberrations by pylorus ligation (70.05%) and ethanol (78.16%) as judged by their altered biochemical parameters such as free acidity, total acidity, total carbohydrate, total protein and pepsin activity. Furthermore, macroscopic examination of rat’s stomach also showed that the pretreatment with methanolic extract notably lowered the pylorus ligation and ethanol induced ulcers. As perceived in the present study, evidently, our findings basically supports the potency of the methanol extracts of C. setosa to treat gastrointestinal related disorders, thus lends pharmacological credence to the suggested folklore use.

【 授权许可】

Unknown