Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers

Molecules

Barry Neun¹  Eric E. Simanek²  Alan E. Enciso³  Marina A. Dobrovolskaia⁴  Jamie Rodriguez⁵  Amalendu P. Ranjan⁵ 

[1] Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA;Institute of Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76109, USA;;Department of Chemistry &;Department of Molecular and Medical Genetics &Nanotechnology Characterization Lab, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA;

关键词: dendrimer;    triazine;    PAMAM;    platelet;    biocompatibility;   

DOI  :  10.3390/molecules21040428

来源: DOAJ

【 摘 要 】

Triazine and PAMAM dendrimers of similar size and number of cationic surface groups were compared for their ability to promote platelet aggregation. Triazine dendrimers (G3, G5 and G7) varied in molecular weight from 8 kDa–130 kDa and in surface groups 16–256. PAMAM dendrimers selected for comparison included G3 (7 kDa, 32 surface groups) and G6 (58 kDa, 256 surface groups). The treatment of human platelet-rich plasma (PRP) with low generation triazine dendrimers (0.01–1 µM) did not show any significant effect in human platelet aggregation in vitro; however, the treatment of PRP with larger generations promotes an effective aggregation. These results are in agreement with studies performed with PAMAM dendrimers, where large generations promote aggregation. Triazine dendrimers promote aggregation less aggressively than PAMAM dendrimers, a factor attributed to differences in cationic charge or the formation of supramolecular assemblies of dendrimers.

【 授权许可】

Unknown