Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19

The Korean Journal of Internal Medicine

Ji-Yeon Kim¹  Dong-Min Kim²  Sin Young Ham³  Eu Suk Kim³  Hyeonju Jeong³  Hong Bin Kim³  Kyoung-Ho Song³  Sang-Min Oh³  Jongtak Jung³  Chang Kyung Kang⁴  Jeong Su Park⁵  Kyoung Un Park⁵  Ji Young Park⁶  Hyunju Lee⁶  Yu Min Kang⁷ 

[1] Department of Infectious Diseases, Seongnam Citizens Medical Center, Seongnam, Korea;Department of Internal Medicine, Chosun University Hospital, Gwangju, Korea;Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea;Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea;Division of Infectious Diseases, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea;

关键词: reinfection;    covid-19;    severe acute respiratory syndrome coronavirus 2;   

DOI  :  10.3904/kjim.2020.325

来源: DOAJ

【 摘 要 】

Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regarding the medical measures and policies. We evaluated the dynamics of viral load and anti-SARS-CoV-2 antibodies in four patients with positive RT-PCR results after recovery. In all patients, the highest levels of immunoglobulin G (IgG) and IgM antibodies were reached after about a month of the onset of the initial symptoms. Then, the IgG titers plateaued, and the IgM titers decreased, regardless of RT-PCR results. The IgG and IgM levels did not increase after the post-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to the detection of RNA particles rather than reinfection in individuals who have recovered from COVID-19.

【 授权许可】

Unknown