期刊论文详细信息
Frontiers in Neuroscience
ShinyCortex: Exploring Single-Cell Transcriptome Data From the Developing Human Cortex
Barbara Treutlein1  Damian Wollny2  Jorge Kageyama2  J. Gray Camp2 
[1] Department of Biosciences, Technical University Munich, Munich, Germany;Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany;Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany;
关键词: single cell RNA sequencing;    cortex development;    organoids;    corticogenesis;    single-cell transcriptomics;   
DOI  :  10.3389/fnins.2018.00315
来源: DOAJ
【 摘 要 】

Single-cell mRNA sequencing (scRNA-seq) is a powerful method to identify and classify cell types and reconstruct differentiation trajectories within complex tissues, such as the developing human cortex. scRNA-seq data also enables the discovery of cell type-specific marker genes and genes that regulate developmental transitions. Here we provide a brief overview of how scRNA-seq has been shaping the study of human cortex development, and present ShinyCortex, a resource that brings together data from recent scRNA-seq studies of the developing cortex for further analysis. ShinyCortex is based in R and displays recently published scRNA-seq data from the human and mouse cortex in a comprehensible, dynamic and accessible way, suitable for data exploration by biologists.

【 授权许可】

Unknown   

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