Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus

Journal of Clinical Medicine

Giuseppe Di Gioia¹  Jozef Bartunek¹  Iginio Colaiori¹  Teresa Strisciuglio²  Antonio Rapacciuolo²  MariaVirginia Manzi²  Raffaele Izzo²  Danilo Franco²  Carmine Morisco²  Costantino Mancusi²  Bruno Trimarco²  Emanuele Barbato²  MariaAngela Losi²  Giovanni de Simone² 

[1] Cardiovascular Research Center Aalst OLV Hospital, 9300 Aalst, Belgium;Department of Advanced Biomedical Sciences, University of Naples Federico II, 80100 Napoli, Italy;

关键词: coronary artery disease;    diabetes mellitus;    atherosclerosis;    coronary angiography;   

DOI  :  10.3390/jcm8071069

来源: DOAJ

【 摘 要 】

Background: Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is unknown. Objective: We evaluated the onset of DM in relation to the extent and severity of coronary atherosclerosis, using the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score (SS), in patients with stable angina or acute coronary syndromes, referred for coronary angiography (CA). Methods: Non-diabetic patients that underwent CA for the first time were included, and the SS was computed. Predictors of DM onset in low, medium, and high SSs were investigated. Results: Five hundred and seventy patients were included, and the mean SS was 6.3 ± 7.6. During a median follow-up of 79 months (interquartile range (IQR): 67−94), 74 patients (13%) developed DM. The risk of DM onset was significantly higher in the patients with a medium or high SS (hazard ratio (HR)—95% confidence interval (CI): 16 (4−61), p < 0.0001; and 30 (9−105), p < 0.0001, vs low SS, respectively), even after adjustment for obesity, history of hypertension, impaired fasting glucose, and cardiovascular therapy. Conclusions: The severity and extent of the coronary atherosclerosis, evaluated by the SS, is a strong and independent predictor of the development of DM in patients, referred to CA.

【 授权许可】

Unknown