Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress

Biomedicines

Itaru Monno¹  Jing Xu¹  Yoshio Ogura¹  Munehiro Kitada¹  Daisuke Koya¹ 

[1] Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan;

关键词: methionine restriction;    oxidative stress;    autophagy;    lifespan extension;    metabolic health;   

DOI  :  10.3390/biomedicines9020130

来源: DOAJ

【 摘 要 】

Enhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health in organisms from yeast to rodents. The effect of MetR on lifespan extension and metabolic health is mediated partially through a reduction in oxidative stress. Methionine metabolism is involved in the supply of methyl donors such as S-adenosyl-methionine (SAM), glutathione synthesis and polyamine metabolism. SAM, a methionine metabolite, activates mechanistic target of rapamycin complex 1 and suppresses autophagy; therefore, MetR can induce autophagy. In the process of glutathione synthesis in methionine metabolism, hydrogen sulfide (H₂S) is produced through cystathionine-β-synthase and cystathionine-γ-lyase; however, MetR can induce increased H₂S production through this pathway. Similarly, MetR can increase the production of polyamines such as spermidine, which are involved in autophagy. In addition, MetR decreases oxidative stress by inhibiting reactive oxygen species production in mitochondria. Thus, MetR can attenuate oxidative stress through multiple mechanisms, consequently associating with lifespan extension and metabolic health. In this review, we summarize the current understanding of the effects of MetR on lifespan extension and metabolic health, focusing on the reduction in oxidative stress.

【 授权许可】

Unknown