Investigation of factors related to N-terminal pro-B typenatriuretic peptide levels in hemodialysis patients; asingle center study

Journal of Nephropharmacology

Pegah Noorshargh¹  Farbod Bonakdar²  Hamid Nasri²  Parin Hedayati³ 

[1] Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;Hemodialysis Section, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran;

关键词: N-terminal pro-B type natriuretic peptide;    Renal insufficiency;    Renal dialysis;    End-stage renal disease;    Hemodialysis;    Chronic kidney disease;   

DOI  :  10.15171/npj.2020.05

来源: DOAJ

【 摘 要 】

Introduction: Introduction: N-terminal pro-B type natriuretic peptide (NT-proBNP) can be usedto diagnose cardiac and renal disease. The association of NT-pro BNP with demographic, clinicaland biochemical factors in hemodialysis is unclear.Objectives: This study aimed to examine association of NT-pro BNP and mentioned factors inhemodialysis patients.Patients and Methods: This study was conducted on 78 end-stage renal disease (ESRD) patientsunder hemodialysis. Demographic data, lipid profile and electrolytes were recorded. NT-proBNPwas checked simultaneously and its association with mentioned factors were assessed.Results: The average NT-pro BNP level was 890.52±700.87 pg/mL (range: 0.1-3343 pg/mL). Serumlevel of NT-pro BNP was statistically in association with total cholesterol (P=0.002; r=-0.348), lowdensity lipoprotein (LDL) (P=0.09; r= -0.292), high density lipoprotein (HDL) (P=0.06; r=-0.310)and serum triglyceride (P=0.018; r=-0.269) while having a direct relationship with serum ferritin(P=0.022; r=0.274), alkaline phosphatase (ALP) (P=0.048; r=0.224) and duration of hemodialysis(P=0.005; r=0.321).Conclusion: Lipid profile and ferritin are associated with NT-pro BNP levels. This can reflectpossible prognostic role of NT-proBNP among ESRD patients on hemodialysis.

【 授权许可】

Unknown