Glycerol content within the WHO ethanol-based handrub formulation: balancing tolerability with antimicrobial efficacy

Antimicrobial Resistance and Infection Control

Daniela Pires¹  Didier Pittet¹  Mayra Gonçalves Menegueti²  Fernando Bellissimo-Rodrigues²  Anibal Basile-Filho³  Maria Auxiliadora-Martins³  Ana Maria Laus⁴  Elucir Gir⁴  Márcia Aparecida Ciol⁵ 

[1]Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine

[2]Infection Control Service, University Hospital of Ribeirão Preto Medical School, University of São Paulo

[3]Intensive Care Division, Ribeirão Preto Medical School, University of São Paulo

[4]Ribeirão Preto Nursing School, University of São Paul

[5]University of Washington

关键词: Hand hygiene;    World Health Organization;    Alcohol-based hand rub;    Glycerol;    Skin tolerability;    Essential medicines list;   

DOI  :  10.1186/s13756-019-0553-z

来源: DOAJ

【 摘 要 】

Abstract Background The World Health Organization (WHO) ethanol-based handrub (EBHR) formulation contains 1.45% glycerol as an emollient to protect healthcare workers’ (HCWs) skin against dryness and dermatitis. However, glycerol seems to negatively affect the antimicrobial efficacy of alcohols. In addition, the minimal concentration of glycerol required to protect hands remain unknown. We aim to evaluate the tolerance of HCWs to the WHO EBHR formulation using different concentrations of glycerol in a tropical climate healthcare setting. Methods We conducted a cluster-randomized, double-blind, crossover study among 40 HCWs from an intensive care unit of a tertiary-care hospital in Brazil, from June 1st to September 30, 2017. We tested the WHO EBHR original formulation containing 1.45% glycerol against three other concentrations (0, 0.5, and 0.75%). HCWs used one formulation at a time for seven working days during their routine practice and then had their hands evaluated by an external observer using the WHO scale for visual inspection. Participants also used a WHO self-evaluation tool to rate their own skin condition. We used a generalized estimating equations of the logit type to compare differences between the tolerability to different formulations. Results According to the independent observation, participants had 2.4 times (95%CI: 1.12–5.15) more chance of having a skin condition considered good when they used the 0.5% compared to the 1.45% glycerol formulation. For the self-evaluation scale, participants were likely to have a worst evaluation (OR: 0.23, 95%CI: 0.11–0.49) when they used the preparation without glycerol compared to the WHO standard formulation (1.45%), and there were no differences between the other formulations used. Conclusion In a tropical climate setting, the WHO-modified EBHR formulation containing 0.5% glycerol led to better ratings of skin tolerance than the original formulation, and, therefore, may offer the best balance between skin tolerance and antimicrobial efficacy.

【 授权许可】

Unknown