Comparison of the Effect on Fetal Growth of a Mixture of Atrazine and Nitrates in Drinking Water and of Active Tobacco Exposure during Pregnancy

International Journal of Environmental Research and Public Health

Marion Albouy-Llaty¹  Virginie Migeot¹  Sylvie Rabouan²  Antoine Dupuis²  Camille Carles³ 

[1] CHU Poitiers, Department of Public Health, F-86021 Poitiers, France;INSERM CIC 1402, CHU Poitiers, F-86021 Poitiers, France;University Bordeaux, INSERM UMR 1219, Equipe EPICENE, F33000 Bordeaux, France;

关键词: endocrine-disrupting compounds;    mixture;    fetal growth;    active tobacco exposure;    drinking water;   

DOI  :  10.3390/ijerph18042200

来源: DOAJ

【 摘 要 】

Active tobacco exposure during pregnancy is a known determinant of fetal growth. Nitrates and atrazine metabolites in drinking water may affect fetal growth as a mixture of endocrine disruptors (ED). We aimed to determine whether EDC have an additional effect on fetal growth compared to active tobacco exposure. A historic cohort study was carried out with a sample stratified with regard to the maternity unit, drinking water exposure, and year of birth. The women included were living in Deux-Sèvres, had given birth between 2005 and 2010 in three selected maternity units, and ultrasound data were available in their obstetrical records. Mixed linear models were used to analyze fetal weight evolution from the second trimester to the time of birth according to drinking water exposure to EDC mixture and active tobacco exposure. We included 558 mother-neonate couples, of whom 9% were exposed to high doses of the mixture and 21% to active tobacco smoking. There was no difference in fetal weight evolution according to drinking water mixture exposure (0.97 g; 95% CI [−3.01; 4.94]). We could not show a supplementary effect of mixture exposure in drinking-water on fetal growth as compared to active tobacco exposure. Further research is needed, using more precise methods to estimate EDC exposure.

【 授权许可】

Unknown