Pedunculopontine arousal system physiology – Implications for insomnia

Sleep Science

Susan Mahaffey¹  Brennon Luster¹  Edgar Garcia-Rill¹  Veronica Bisagno²  Francisco J. Urbano² 

[1] Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USA;IFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, Argentina;

关键词: Calcium channels;    Gamma band activity;    Neuronal calcium sensor protein;    N-type calcium channel;    P/Q-type calcium channel;   

DOI  :  10.1016/j.slsci.2015.06.002

来源: DOAJ

【 摘 要 】

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.

【 授权许可】

Unknown