Probiotic Supplementation for Promotion of Growth in Children: A Systematic Review and Meta-Analysis

Nutrients

Zulfiqar A. Bhutta¹  Emily Tanner-Smith²  Julie M. Ehrlich³  Muizz Zaman³  Elizabeth Stone³  Joseph Catania³  Natasha G. Pandit³  Courtney Franceschi³  Joseph P. Zackular⁴  Aamer Imdad⁵  Abigail Smith⁶ 

[1] Centre for Global Child Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;College of Education, University of Oregon, Eugene, OR 97403, USA;College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA;Department of Pathology, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA;Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, SUNY Upstate Medical University, Syracuse, NY 13210, USA;Health Science Library, SUNY Upstate Medical University, Syracuse, NY 13210, USA;

关键词: probiotics;    synbiotics;    growth;    low- and middle-income countries;    high-income countries;    systematic review;   

DOI  :  10.3390/nu14010083

来源: DOAJ

【 摘 要 】

Probiotics are commonly prescribed to promote a healthy gut microbiome in children. Our objective was to investigate the effects of probiotic supplementation on growth outcomes in children 0–59 months of age. We conducted a systematic review and meta-analysis which included randomized controlled trials (RCTs) that administered probiotics to children aged 0–59 months, with growth outcomes as a result. We completed a random-effects meta-analysis and calculated a pooled standardized mean difference (SMD) or relative risk (RR) and reported with a 95% confidence interval (CI). We included 79 RCTs, 54 from high-income countries (HIC), and 25 from low- and middle-income countries (LMIC). LMIC data showed that probiotics may have a small effect on weight (SMD: 0.26, 95% CI: 0.11–0.42, grade-certainty = low) and height (SMD 0.16, 95% CI: 0.06–0.25, grade-certainty = moderate). HIC data did not show any clinically meaningful effect on weight (SMD: 0.01, 95% CI: −0.04–0.05, grade-certainty = moderate), or height (SMD: −0.01, 95% CI: −0.06–0.04, grade-certainty = moderate). There was no evidence that probiotics affected the risk of adverse events. We conclude that in otherwise healthy children aged 0–59 months, probiotics may have a small but heterogenous effect on weight and height in LMIC but not in children from HIC.

【 授权许可】

Unknown