HOXA5 Is Recognized as a Prognostic-Related Biomarker and Promotes Glioma Progression Through Affecting Cell Cycle

Frontiers in Oncology

Wenhua Piao²  Fengqin Ding²  Quan Cheng³  Pengfei Bie⁴  Ping Chen⁶ 

[1]Clinical Diagnosis and Therapy Center for Glioma of Xiangya Hospital, Central South University, Changsha, China

[2]Department of Clinical Laboratory, People’s Hospital of Ningxia Hui Autonomous Region, First Affiliated Hospital of Northwest Minzu University, Yinchuan, China

[3]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

[4]Department of Neurosurgery, People’s Hospital of Ningxia Hui Autonomous Region, First Affiliated Hospital of Northwest Minzu University, Yinchuan, China

[5]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China

[6]Medical Experiment Center, General Hospital of Ningxia Medical University, Yinchuan, China

[7]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

关键词: homeobox A5;    glioma;    cell cycle;    cell proliferation;    prognosis;   

DOI  :  10.3389/fonc.2021.633430

来源: DOAJ

【 摘 要 】

Glioma is malignant tumor derives from glial cells in the central nervous system. High-grade glioma shows aggressive growth pattern, and conventional treatments, such as surgical removal and chemo-radiotherapy, archive limitation in the interference of this process. In this work, HOXA5, from the HOX family, was identified as a glioma cell proliferation-associated factor by investigating its feature in the TCGA and CGGA data set. High HOXA5 expression samples contain unfavorable clinical features of glioma, including IDH wild type, un-methylated MGMT status, non-codeletion 1p19q status, malignant molecular subtype. Survival analysis indicates that high HOXA5 expression samples are associated with worse clinical outcome. The CNVs and SNPs profile difference further confirmed the enrichment of glioma aggressive related biomarkers. In the meantime, the activation of DNA damage repair-related pathways and TP53-related pathways is also related to HOXA5 expression. In cell lines, U87MG and U251, by interfering HOXA5 expression significantly inhibit glioma progression and apoptosis, and cell cycle is arrested at the G2/M phase. Collectively, increased HOXA5 expression can promote glioma progression via affecting glioma cell proliferation.

【 授权许可】

Unknown