The Role of Mineralocorticoid Receptor Signaling in Genitourinary Cancers

Nuclear Receptor Research

Yujiro Nagata¹  Hiroshi Miyamoto¹  Takuro Goto¹ 

[1] Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA;

关键词: Antagonists;    mineralocorticoid receptor;    prostatic adenocarcinoma;    renal cell carcinoma;    urothelial cancer;   

DOI  :  10.32527/2019/101410

来源: DOAJ

【 摘 要 】

A steroid hormone receptor, mineralocorticoid receptor (MR), is well known to play a critical role in maintaining normal homeostasis in the body primarily via regulating ionic and water transports. Indeed, MR antagonists have been prescribed to the patients as diuretic drugs. Meanwhile, emerging evidence has indicated that MR signaling, with or without functional interplay with glucocorticoid receptor or androgen receptor, contributes to modulating the development and progression of several types of neoplasms including genitourinary malignancies. This review summarizes the available data suggesting the involvement of MR signaling in renal cell carcinoma, prostatic adenocarcinoma, urothelial carcinoma, and other malignancies, and highlights potential underlying molecular mechanisms.

【 授权许可】

Unknown