Effect of Deep Brain Stimulation on Swallowing Function: A Systematic Review

Frontiers in Neurology

Tao Xie²  Huiyan Yu²  Samuel D. Quaynor²  Kazutaka Takahashi³  Lisa Bloom⁴ 

[1] Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing, China;Department of Neurology, The University of Chicago Medicine, Chicago, IL, United States;Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL, United States;Speech and Swallowing Service, The University of Chicago Medicine, Chicago, IL, United States;

关键词: deep brain stimulation (DBS);    dysphagia;    swallowing function;    subthalamic nucleus (STN);    globus pallidus interna (GPi);    post-subthalamic area (PSA);   

DOI  :  10.3389/fneur.2020.00547

来源: DOAJ

【 摘 要 】

The effect of deep brain stimulation (DBS) on swallowing function in movement disorders is unclear. Here, we systematically reviewed this topic by searching keywords following PICOS strategy of problem (swallowing or swallow or dysphagia or aspiration) and intervention (deep brain stimulation, or DBS) in the PubMed and Web of Science in English in April 2020, with comparators [subthalamic nucleus (STN), globus pallidus interna (GPi), ventralis intermedius, (ViM), post-subthalamic area, or caudal zona incerta (PSA/cZi); ON/OFF DBS state/settings, ON/OFF medication state, Parkinson's disease (PD), dystonia, tremor], outcomes (swallowing function measures, subjective/objective) and study types (good quality original studies) in mind. We found that STN DBS at usual high-frequency stimulation could have beneficial effect (more so on subjective measures and/or OFF medication), no effect, or detrimental effect (more so on objective measures and/or ON medication) on swallowing function in patients with PD, while low-frequency stimulation (LFS) could have beneficial effect on swallowing function in patients with freezing of gait. GPi DBS could have a beneficial effect (regardless of medication state and outcome measures) or no effect, but no detrimental effect, on swallowing function in PD. GPi DBS also has beneficial effects on swallowing function in majority of the studies on Meige syndrome but not in other diseases with dystonia. PSA/cZi DBS rarely has detrimental effect on swallowing functions in patients with PD or tremor. There is limited information on ViM to assess. Information on swallowing function by DBS remains limited. Well-designed studies and direct comparison of targets are further needed.

【 授权许可】

Unknown