Cortical and subcortical functional specificity associated with response inhibition

NeuroImage

C. John Evans¹  Christopher P.G. Allen²  Nils Muhlert²  Leah Maizey²  Christopher D. Chambers³  Frederick Verbruggen⁴ 

[1] Corresponding authors.;Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, United Kingdom;Department of Experimental Psychology, Ghent University, Belgium;Division of Neuroscience and Experimental Psychology, University of Manchester, United Kingdom;

关键词: Response inhibition;    Response execution;    Action control;    Action updating;    Basal ganglia;    Action pathways;   

DOI  :  

来源: DOAJ

【 摘 要 】

Is motor response inhibition supported by a specialised neuronal inhibitory control mechanism, or by a more general system of action updating? This pre-registered study employed a context-cueing paradigm requiring both inhibitory and non-inhibitory action updating in combination with functional magnetic resonance imaging to test the specificity of responses under different updating conditions, including the cancellation of actions. Cortical regions of activity were found to be common to multiple forms of action updating. However, functional specificity during response inhibition was observed in the anterior right inferior frontal gyrus. In addition, fronto-subcortical activity was explored using a novel contrast method. These exploratory results indicate that the specificity for response inhibition observed in right prefrontal cortex continued downstream and was observed in right hemisphere subcortical activity, while left hemisphere activity was associated with right-hand response execution. Overall, our findings reveal both common and distinct correlates of response inhibition in prefrontal cortex, with exploratory analyses supporting putative models of subcortical pathways and extending them through the demonstration of lateralisation.

【 授权许可】

Unknown