Dietary absorption profile, bioavailability of (poly)phenolic compounds, and acute modulation of vascular/endothelial function by hazelnut skin drink

Journal of Functional Foods

Daniela Martini¹  Furio Brighenti¹  Letizia Bresciani²  Daniele Del Rio³  Melanie Charron³  Melina Tsiountsioura³  Sumantra Ray⁴  Gabriele Mocciaro⁴  Pedro Mena⁴  Matt Harvey⁵  Stefano Bentley⁶  David Collins⁶ 

[1] The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, University of Parma, Via Volturno, 39, 43125 Parma, Italy;The Need for Nutrition Education/Innovation Programme (NNEdPro) Global Centre for Nutrition and Health, St John’s Innovation Centre, Cambridge CB4 0WS, UK;Department of Veterinary Science, University of Parma, Via Volturno, 39, 43125 Parma, Italy;Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Rd, Cambridge CB1 9NL, UK;Soremartec Italia, Ferrero Group, Piazzale Pietro Ferrero, 1, 12051 Alba, CN, Italy;The Laboratory of Phytochemicals in Physiology, Human Nutrition Unit, University of Parma, Via Volturno, 39, 43125 Parma, Italy;

关键词: Hazelnut skin drink;    Flavan-3-ols;    Absorption;    Endothelial effect;    Bioavailability;   

DOI  :  

来源: DOAJ

【 摘 要 】

Evidence supports an inverse association between nut consumption and cardiovascular disease (CVD) risk and (poly)phenols have been identified as potential co-mediators of these beneficial effects. This study investigated the acute absorption and the bioavailability of (poly)phenols of a hazelnut skin drink in healthy subjects and assessed its acute impact on vascular/endothelial function. A single-blind, non-randomised unilateral cross-over trial involved 41 healthy adults. Blood and urine were collected resulting in the detection of ten plasma and twenty-four urine metabolites. Bioavailability was estimated about 27%. The acute ingestion of the test drink did not show any statistically significant changes to vascular/endothelial function, although a trend was observed with high-producers of certain secondary metabolites. These results indicate that the hazelnut skin drink contains an important fraction of bioavailable bioactive compounds. However, no significant acute effects of the test drink on vascular/endothelial function were observed. The study has been registered on http://www.isrctn.com.

【 授权许可】

Unknown