Serological Response to BNT162b2 Anti-SARS-CoV-2 Vaccination in Patients with Inflammatory Rheumatic Diseases: Results From the RHEUVAX Cohort

Frontiers in Immunology

Maria Vittoria Montemurro¹  Antonio Giordano²  Maria Teresa Vietri³  Piero Ruscitti⁴  Maria Dora Pasquale⁵  Gelsomina Rozza⁵  Carlo Cannistrà⁵  Giuseppe Scalise⁵  Laura Bucci⁵  Silvia Scriffignano⁵  Antonio Ciancio⁵  Daniele Mauro⁵  Flavia Riccio⁵  Martina Patrone⁵  Claudio Di Vico⁵  Ilenia Pantano⁵  Luana Passariello⁶  Francesco Ciccia⁶ 

[1] Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy;Clinical Directorate, University Hospital of Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy;Head Office, University Hospital of Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy;;Rheumatology Unit, Department of Biotechnological &Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania “L.Vanvitelli”, Naples, Italy;Unit of Clinical and Molecular Pathology, Department of Precision Medicine, Università degli Studi della Campania “L.Vanvitelli”, Naples, Italy;

关键词: COVID-19;    vaccines;    autoimmunity;    rheumatic and muscoluskeletal disease;    arthritis;    connective tissue disease (CTD);   

DOI  :  10.3389/fimmu.2022.901055

来源: DOAJ

【 摘 要 】

ObjectiveIn the light of the current COVID-19 epidemic and the availability of effective vaccines, this study aims to identify factors associated with non-response to anti-SARS-CoV-2 vaccines as immunological alteration associated with immune rheumatic diseases (IRD) and immunosuppressive medications may impair the response to vaccination.MethodsVolunteers in the health profession community with IRD, age, and sex-matched controls (CTRL) who underwent vaccination with two doses of BNT162b2 were recruited for this study. Anti-Trimeric Spike protein antibodies were assayed eight ± one weeks after the second vaccine dose. Univariate and logistic regression analyses were performed to identify factors independently associated with non-response and low antibody titers.ResultsSamples were obtained from 237 IRD patients (m/f 73/164, mean age 57, CI 95% [56-59]): 4 autoinflammatory diseases (AI), 62 connective tissue diseases (CTD), 86 rheumatoid arthritis (RA), 71 spondylarthritis (SpA) and 14 vasculitis (Vsc). 232 CTRL were recruited (m/f 71/161, mean age 57, CI 95% [56-58]). Globally, IRD had a lower seroconversion rate (88.6% vs 99.6%, CI 95% OR [1.61-5.73], p<0.001) and lower antibody titer compared to controls (median (IQR) 403 (131.5-1012) versus 1160 (702.5-1675), p<0.001). After logistic regression, age, corticosteroid (CCS), Abatacept and Mycophenolate Mofetil (MMF) use were associated with non-response. Lower antibody titer was associated with the use of MMF, ABA, CCS, Rituximab, tumor necrosis factor inhibitor, JAK inhibitors, and higher age.ConclusionThe response to anti-SARS-CoV-2 vaccines is often impaired in IRD patients under treatment and may pose them at higher risk of severe COVID-19. Specific vaccination protocols are desirable for these patients.

【 授权许可】

Unknown