Intraocular Tuberculosis: A Challenging Case Mimicking Wet Age-Related Macular Degeneration

Case Reports in Ophthalmology

Cristina Ciabattoni¹  Erika Mandarಠ Alessandra Cuna²  Alessandro Papayannis³  Emanuela Interlandi⁴  Rocco De Marco⁴  Marco De Luca⁴  Tatiana Liberali⁵  Francesco Pellegrini⁵  Antonio Zappacosta⁵  Daniele Cirone⁶  Carlos Pavesio⁷  Loredana Latanza⁸ 

[1] Department of Ophthalmology, “A. Murri” Hospital, Fermo, Italy;Department of Ophthalmology, “De Gironcoli” Hospital, Conegliano, Italy;Department of Ophthalmology, “Monfalcone-Gorizia A.S.U.G.I.,”, Monfalcone, Italy;Department of Ophthalmology, “Ospedale del Mare” Hospital, Naples, Italy;Department of Ophthalmology, “Santo Spirito” Hospital, Pescara, Italy;Department of Ophthalmology, “Villa Anna” Hospital, San Benedetto del Tronto, Italy;Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom;Private Practice “Dr. Latanza,”, Naples, Italy;

关键词: choroidal neovascularization;    ocular tuberculosis;    choroidal granuloma;   

DOI  :  10.1159/000512578

来源: DOAJ

【 摘 要 】

An otherwise healthy 72-year-old Chinese patient diagnosed with exudative age-related macular degeneration and decreased vision in left eye was fully investigated. The retrospective analysis of past multimodal imaging revealed bilateral severe choroidal neovascularization and choroiditis associated with a positive tuberculin skin testing and interferon-gamma release assay (QuantiFERON-TB Gold – Cellestis®, Chadstone, VIC, Australia) suggestive of latent ocular tuberculosis. The variable presentation and tests’ results interpretation represent the greatest limitations in understanding and treating intraocular TB (IOTB). This may present without any other systemic symptoms, the intraocular tissues are of limited access to biopsies and other tests, including imaging and immunological tests, are of relative value. This case highlights how variable may be the presentation of IOTB, which can be easily misdiagnosed leading to a delayed treatment and worse prognosis.

【 授权许可】

Unknown