Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma

Interdisciplinary Neurosurgery

John W. Henson¹  Timothy A. Gregory² 

[1] Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Medical Center, Seattle, WA, United States;Department of Medicine, Neurology, Madigan Army Medical Center, Tacoma, WA, United States;

关键词: Glioblastoma;    Neuroimaging;    Cortical lesions;   

DOI  :  

来源: DOAJ

【 摘 要 】

Early MRI findings in GBM can include ill-defined T2-hyperinsities throughout grey and white matter, often with enhancement. Outside of animal models and a single prior case series, little has been reported on GBM manifesting within cortex. We report a series of three patients in whom GBM initially presented with early cortical findings, indicating that grey matter lesions can be the first detectable radiographic feature in a subset of patients. New-onset seizures may present with similar cortical ribbon changes, creating a diagnostic challenge as illustrated by two of our reported cases who initially presented with seizures and cortical abnormalities. Our series highlights the imperative for short interval imaging follow-up in such patients and indicates the need to consider suspicious cortical lesions when planning the radiation treatment field.

【 授权许可】

Unknown