A new role for extracellular vesicles: how small vesicles can feed tumors' big appetite

Journal of Lipid Research

Ikrame Lazar¹  Camille Attane¹  Catherine Muller¹  Emily Clement¹  Laurence Nieto² 

[1] Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 31077 Toulouse Cedex, France and Université de Toulouse, UPS, IPBS, F-31077, 31062 Toulouse Cedex, France;To whom correspondence should be addressed.;

关键词: adipocytes;    cancer;    fatty acid metabolism;    fatty acid oxidation;    fatty acid synthesis;    tumor microenvironment • exosomes • microvesicles • obesity • biomarker;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cancer cells must adapt their metabolism in order to meet the energy requirements for cell proliferation, survival in nutrient-deprived environments, and dissemination. In particular, FA metabolism is emerging as a critical process for tumors. FA metabolism can be modulated through intrinsic changes in gene expression or signaling between tumor cells and also in response to signals from the surrounding microenvironment. Among these signals, extracellular vesicles (EVs) could play an important role in FA metabolism remodeling. In this review, we will present the role of EVs in tumor progression and especially in metabolic reprogramming. Particular attention will be granted to adipocytes. These cells, which are specialized in storing and releasing FAs, are able to shift tumor metabolism toward the use of FAs and, subsequently, increase tumor aggressiveness. Recent work demonstrates the involvement of EVs in this metabolic symbiosis.

【 授权许可】

Unknown