Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1

Frontiers in Physiology

Je Min Lee¹  Inhwa Yeam²  Md. Mahi Imam Mollah³  Hyong Woo Choi³  Yonggyun Kim³ 

[1] Department of Horticultural Science, Kyungpook National University, Daegu, South Korea;Department of Horticulture and Breeding, Andong National University, Andong, South Korea;Department of Plant Medicals, Andong National University, Andong, South Korea;

关键词: salicylic acid;    eicosanoid;    HMGB1;    immunity;    insect;   

DOI  :  10.3389/fphys.2021.744272

来源: DOAJ

【 摘 要 】

Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect homolog of HMGB1. In this study, a DSP1 (Se-DSP1) encoded in Spodoptera exigua, a phytophagous insect, was characterized, and its potential role in immune response was explored. Upon bacterial challenge, Se-DSP1 was localized in the nucleus and released into the hemolymph. The released Se-DSP1 could mediate both cellular and humoral immune responses by activating eicosanoid biosynthesis. Salicylic acid could bind to Se-DSP1 with a high affinity. The immune responses of S. exigua were significantly interrupted by SA feeding. Larvae reared on tomatoes with high endogenous SA levels became more susceptible to entomopathogens. Taken together, these results suggest a tritrophic defensive role of plant SA against phytophagous insects.

【 授权许可】

Unknown