Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors

Molecules

Blas Lotina-Hennsen¹  Beatriz King-Diaz¹  BarbaraSayuri Bellete²  OlíviaMoreira Sampaio³  MariaFátima das Graças Fernandes da Silva⁴  ThiagoAndré Moura Veiga⁵  LucasCampos Curcino Vieira⁶ 

[1] Department of Biochemistry, University Nacional Autonoma de Mexico, Mexico City 04510, Mexico;Department of Chemistry, Federal University of Lavras, Minas Gerais-MG 37200-000, Brazil;Department of Chemistry, Federal University of Mato Grosso, Cuiabá-MT 78068-600, Brazil;Department of Chemistry, Federal University of São Carlos, São Carlos-SP 13565-905, Brazil;Department of Chemistry, Federal University of São Paulo, Diadema-SP 09972-270, Brazil;Engineering Institute, Federal University of Mato Grosso, Várzea Grande-MT 78060-900, Brazil;

关键词: Ruta graveolens;    photosystem II;    Chl a fluorescence;    Hill reaction inhibitors;    acridone alkaloids;   

DOI  :  10.3390/molecules23102693

来源: DOAJ

【 摘 要 】

Eight alkaloids (1–8) were isolated from Ruta graveolens, and their herbicide activities were evaluated through in vitro, semivivo, and in vivo assays. The most relevant results were observed for Compounds 5 and 6–8 at 150 μM, which decreased dry biomass by 20% and 23%, respectively. These are significant results since they presented similar values with the positive control, commercial herbicide 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). Based on the performed assays, Compound 5 (graveoline) is classified as an electron-transport inhibitor during the light phase of photosynthesis, as well as a plant-growth regulator. On the other hand, Compounds 6–8 inhibited electron and energy transfers, and are also plant-growth inhibitors. These phytotoxic behaviors based on acridone and quinolone alkaloids may serve as a valuable tool in the further development of a new class of herbicides since natural products represent an interesting alternative to replace commercial herbicides, potentially due their low toxicity.

【 授权许可】

Unknown